Evaluation of Diffusion Tensor Imaging Findings in Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis PatientsÖzkan Alataş1, Berrin Çavuşoğlu2, Ali Çaylak3, Ahmet Onur Keskin4, Egemen İdiman5, Fethi İdiman5, Emel Ada11Dokuz Eylul University Faculty of Medicine, Department of Radiology, Izmir, Türkiye 2Dokuz Eylul University Institute of Health Sciences, Department of Medical Physics, Izmir, Türkiye 3Special Akhisar Hospital, Clinic of Radiology, Manisa, Türkiye 4Baskent University Faculty of Medicine, Department of Neurology, Adana, Türkiye 5Dokuz Eylul University Faculty of Medicine, Department of Neurology, Izmir, Türkiye
Objective: To compare diffusion tensor imaging (DTI) findings of the normal-appearing white matter (NAWM) and corpus callosum (CC) in patients with clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RRMS) and a healthy control (HC) group. Materials and Methods: The CIS (n = 10), RRMS (n = 29), and HC (n = 13) groups were evaluated by DTI in this retrospective study. Mean diffusion (MD) and fractional anisotropy (FA) maps as well as MD and FA measurements were made from the corpus callosum genu (CCG), corpus callosum splenium (CCS), and NAWM areas from the frontal, parietal, occipital and temporal lobes. Results: The mean FA values of the NAWM in the temporal lobes were bilaterally lower in both the CIS and RRMS groups than in the HC group. However, no difference was found between the CIS and RRMS groups. In addition, the CIS group had lower FA values in the CCG, whereas the RRMS group had lower FA values in the CCS compared with the HC group. The MD values were significantly different in the CCG between the RRMS and HC groups. Conclusion: DTI contributes to detecting early changes in the NAWM and CC in patients diagnosed with CIS and RRMS. Additionally, DTI can aid in the follow-up care and management of these patients.
Keywords: Clinically isolated syndrome, relapse-remitting multiple sclerosis, diffusion tensor imaging
Özkan Alataş, Berrin Çavuşoğlu, Ali Çaylak, Ahmet Onur Keskin, Egemen İdiman, Fethi İdiman, Emel Ada. Evaluation of Diffusion Tensor Imaging Findings in Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis Patients. Turk J Neurol. 2023; 29(1): 40-45
Corresponding Author: Berrin Çavuşoğlu, Türkiye |
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