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  Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism in Migraine Patients [Turk J Neurol]
Turk J Neurol. 2009; 15(4): 161-165

Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism in Migraine Patients

Belgin Alaşehirli1, Mehmet Gür2, Aylin Akçalı3, Sırma Geyik4, Binnur Bülbül5, Derya Sayar6, Mustafa Yılmaz3, Abdurrahman Neyal7, Münife Neyal3
1Department of Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
2Iskenderun State Hospital, Iskenderun, Hatay, Turkey
3Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
4Clinic of Neurology, Medical Park Hospital, Gaziantep, Turkey
5Clinic of Neurology, Mega Park Hospital, Kahramanmaras, Turkey
6Clinic of Neurology, Gaziantep 25 Aralik State Hospital, Gaziantep, Turkey
7Clinic of Neurology, Gaziantep Cengiz Gokcek State Hospital, Gaziantep, Turkey

OBJECTIVE: The beneficial effects of angiotensin converting enzyme inhibitor drugs on migraine attack frequency have been shown. We aimed to study the relationship between the angiotensin converting enzyme gene and migraine pathophysiology.
METHODS: In the present study, to assess whether the angiotensin converting enzyme insertion/deletion (I/D) gene polymorphisms have an effect on migraine attacks, we studied the angiotensin converting enzyme genotypes of 102 migraine patients (35 cases of migraine with aura and 67 of migraine without aura) and 75 age-and sex-matched normal volunteers. Frequency and age of onset of migraine attacks were also assessed according to angiotensin converting enzyme genotypes.
RESULTS: Patients with migraine with and without aura were comparable with each other and the control group with respect to angiotensin converting enzyme genotypes (respectively; p= 0.88 and p= 0.76, p= 0.624). We could not determine a relationship between angiotensin converting enzyme genotypes and attack frequency (p= 0.125), but cases with angiotensin converting enzyme-II genotype showed a significantly younger age for onset of migraine attacks in comparison with the I/D genotype patients (p= 0.021).
CONCLUSION: We believe that further angiotensin converting enzyme gene studies are warranted in younger age groups of patients with migraine and also in different populations.

Keywords: Angiotensin-converting enzyme, polymorphism, genetic, migraine disorders.

Belgin Alaşehirli, Mehmet Gür, Aylin Akçalı, Sırma Geyik, Binnur Bülbül, Derya Sayar, Mustafa Yılmaz, Abdurrahman Neyal, Münife Neyal. Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism in Migraine Patients. Turk J Neurol. 2009; 15(4): 161-165

Corresponding Author: Münife Neyal, Türkiye

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