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Turkish Journal of Neurology Indexed By
  P300 And P300 Topographic Mapping in Alzheimer's Disease [Turk J Neurol]
Turk J Neurol. 1995; 1(4): 211-216

P300 And P300 Topographic Mapping in Alzheimer's Disease

Raif ÇAKMUR1, Fethi İDİMAN2, Görsev YENER2, Şakir FADILOĞLU2, Birsen KESKİN1
1Dokuz Eylül Üni. Tıp Fak. Nöroloji AD, İZMİR
2Dokuz Eylül Üni. Tıp Fak. Nöroloji AD,İZMİR

Although P300 activity have been widely investigated in dementia of Alzheimer's type(DAT), there have been relatively few number of studies investigating P300 topography. In order to evaluate significance of changes in topography of P300 activity, we prospectively studied 23 patients with DAT and 15 healthy controls. Changes in latency, amplitude and topography of P300 activity were detected with P300 mapping, which was elicited by standard auditory oddball paradigm and recorded from the 10-20 system electrod localizations with linked-ears reference. P300 latencies were significantly longer(434.2-63.3 msec) than controls. P300 amplitudes were not significantly different fromcontrols. Topographically, P300 activity was most prominent in the parieto-central region in controls, whereas it was more anteriorly localized in 8 of 23 patients with DAT However, this anteriorization observed on mapping did not reach statistical significance, probably because of limited number of subjects. We concluded that the topographical evaluation of P300 activity may contribute to detect the cognitivefunctioning in DAT

Keywords: Event related potentials, Brain Mapping, P300, Dementia


Raif ÇAKMUR, Fethi İDİMAN, Görsev YENER, Şakir FADILOĞLU, Birsen KESKİN. P300 And P300 Topographic Mapping in Alzheimer's Disease. Turk J Neurol. 1995; 1(4): 211-216

Corresponding Author: Raif ÇAKMUR


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