Corticobasal Syndrome as Alzheimer's Disease Subtype: A Case Report

Typical Alzheimer's disease is a chronic neurodegenerative disease centered on progressive amnestic disorder. However, it may present atypically with various non-amnestic clinical profiles of other focal cortical dementia syndromes depending on the brain areas affected. One of these atypical forms is the corticobasal syndrome, which is not included in the Alzheimer's Disease Diagnostic Criteria published by the National Institute of Aging - Alzheimer's Association in 2011 and the International Working Group-2 in 2014, but is well known by behavioral neurologists. In this study, a sixty-one-year-old male patient with asymmetric parkinsonism, myoclonus, pyramidal findings, primitive reflexes and cranial imaging findings evaluated as corticobasal syndrome and cerebrospinal fluid biomarkers compatible with Alzheimer's disease pathology will be described. Corticobasal syndrome, which is not included in the current diagnostic criteria, but is known to be associated with Alzheimer's Disease pathology in a considerable number of cases, should not be ignored in the new Alzheimer's disease diagnosis criteria to be determined in the future.