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  Orolingual Angioedema After Intravenous Tissue Plasminogen Activator in a Patient with Insular Cortex Ischemia: A Case Report [Turk J Neurol]
Turk J Neurol. 2020; 26(4): 346-348 | DOI: 10.4274/tnd.2020.04864  

Orolingual Angioedema After Intravenous Tissue Plasminogen Activator in a Patient with Insular Cortex Ischemia: A Case Report

Aydın Talip Yıldoğan1, Fettah Eren2, Şerefnur Öztürk1
1Selcuk University Faculty of Medicine, Department of Neurology, Konya, Turkey
2Konya Training and Research Hospital, Clinic of Neurology, Konya, Turkey

Intravenous tissue plasminogen activator (tPA) increases survival rates without sequelae in acute ischemic stroke. Complications and management of this treatment have become more important with the increasing use of tPA. An 80-year-old male patient was admitted with a sudden-onset speech disorder and loss of strength in his right arm, which started 3 hours ago. Magnetic resonance imaging revealed acute ischemia localized in the left insular cortex. Lip and tongue swelling, difficulty in speaking, and deepening in voice were observed in the 30th minute of infusion. There was mild respiratory distress. Orolingual angioedema was diagnosed. He completely recovered after treatment. Angioedema is a rare but potentially life-threatening complication of tPA. When this clinical symptom occurs, it should be recognized and treated quickly. This report aims to reveal the relationship of this rare complication with the localization of the ischemia.

Keywords: Intravenous thrombolysis, stroke, insula, angioedema


Aydın Talip Yıldoğan, Fettah Eren, Şerefnur Öztürk. Orolingual Angioedema After Intravenous Tissue Plasminogen Activator in a Patient with Insular Cortex Ischemia: A Case Report. Turk J Neurol. 2020; 26(4): 346-348

Corresponding Author: Aydın Talip Yıldoğan, Türkiye


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