Transcranial Magnetic Stimulation in Idiopathic Parkinson’s DiseaseGülbin Yüksel, Geysu Karlıkkaya, Hülya TireliNeurology Clinic 2, Haydarpasa Numune Education And Research Hospital, İstanbul, Turkey
OBJECTIVE: Activating the motor cortex via Transcranial Magnetic Stimulation (TMS) gives information about the central motor neuronal pathways. It has been used to assess the functional integrity of motor neurons and descending pathways in different neurological disorders including Idiopathic Parkinson’s Disease. There are different conclusions from different studies regarding TMS in IPD patients, but the most common finding is an increase in MEP amplitude. The aim of this study was to evaluate the functional integrity of corticomotor neuronal pathways in IPD patients, using TMS. METHODS: We studied 30 IPD patients (21 male, 9 female) and age and sex matched 30 healty controls with TMS. The MEP latency and amplitude was recorded and compared between the patients and controls. The effect of, age of onset, disease duration and disability degree was evaluated. RESULTS: We found no difference between the two groups for MEP latency but there was an increase in MEP ampltiude in patient group. This finding was correlated with disease duration and disability scales, and there was no change with dopaminergic treatment. CONCLUSION: PD is not only a disease of extrapyramidal system and the central motor neuronal pathways are affected early in the disease course.
Keywords: Parkinson’s Disease, Transcranial Magnetic Stimulation (TMS), Motor Evoked Potentials (MEP)
Gülbin Yüksel, Geysu Karlıkkaya, Hülya Tireli. Transcranial Magnetic Stimulation in Idiopathic Parkinson’s Disease. Turk J Neurol. 2006; 12(2): 106-111
Corresponding Author: Gülbin Yüksel, Türkiye |
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