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Correlations between endothelial dysfunction and cerebral imaging in migraine [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-81904

Correlations between endothelial dysfunction and cerebral imaging in migraine

Hikmet Saçmacı1, Meral Mirza2, Şükrü Bişiren3, Selma Gökahmetoğlu4, Recep Saraymen5, Abdullah Talaslıoğlu2
1Bozok University, Faculty of Medicine, Department of Neurology, Yozgat
2Erciyes University, Faculty of Medicine, Department of Neurology, Kayseri
3Erciyes University, Faculty of Medicine, Department of Radiology, Kayseri
4Erciyes University Faculty of Medicine, Department of Microbiology, Kayseri
5Erciyes University Faculty of Medicine, Department of Biochemistry, Kayseri

Objective: Despite its high prevalence, the basic pathophysiological mechanism of migraine is still poorly understood. It was aimed to research endothelial dysfunction in recently diagnosed episodic migraine patients in this study, and to determine whether there was a correlation between endothelial dysfunction and white matter lesions (WMLs) on Magnetic Resonance Imaging (MRI).
Materials and Methods: This study was conducted between 2013 and 2014 years. A total of 51 patients and 27 healthy controls were included in the study. MRI was performed in the patient group. Blood samples were collected to investigate serum level of lipids, thyroid hormones, asymmetric dimethyl arginine (ADMA) and endothelin levels in the patient and control groups. Insulin resistance (HOMA-R, homeostasis model assessment) and brachial artery index (FMD = Flow-mediated dilatation) were investigated in both groups.
Results: WMLs on MRI were present in 40 patients with migraine. FMD was low in migraine patients (p = 0.021). There was a negative correlation between the severity of migraine headache and FMD. A positive correlation was seen between severity of headache and WMLs (p = 0.001). The other blood samples concentrations in both case and control groups were not significantly different. When the blood parameters were evaluated with MRI lesion load, there was a positive correlation with age, cholesterol, LDL, body mass index and triglyceride, and contrary to expectations, there was no relationship with homocysteine. However, there was a significant correlation between insulin resistance and lesion load (p <0.03).
Conclusion: In this study, especially in patients with episodic migraine who have WMLs, the FMD as a marker for endothelial dysfunction was found to be statistically significant. This finding contributes to the pathogenesis of migraine. Especially in patients who need prophylaxis, an endothelial therapeutic drug could be considered as an option.

Keywords: Flow-mediated dilatation, White matter lesions, Migraine, Endothelin




Corresponding Author: Hikmet Saçmacı, Türkiye


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