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  Stiff Person Syndrome-The Less Common Antibody: A Case Report [Turk J Neurol]
Turk J Neurol. 2020; 26(1): 39-41 | DOI: 10.4274/tnd.galenos.2019.80708  

Stiff Person Syndrome-The Less Common Antibody: A Case Report

Hüseyin Nezih Özdemir1, Derya Yöndem1, Seren Kaplan2, Figen Gökçay1
1Ege University Faculty of Medicine, Department of Neurology, Izmir, Turkey
2Ege University Faculty of Medicine, Department of Psychiatry, Izmir, Turkey

Stiff Person syndrome (SPS) is a rare, disabling syndrome characterized by progressive muscle stiffness and axial rigidity. It may have an autoimmune, paraneoplastic or cryptogenic etiology. A 59-year-old woman presented with stiffness and involuntary spasms in the lower extremities. In a neurologic examination, lower extremity and axial rigidity were revealed. Anti-glutamic acid decarboxylase antibody was negative, anti-amphiphysin was antibody positive. She was diagnosed as having SPS. The symptoms were improved after intravenous immunoglobulin and cancer therapy.

Keywords: Stiff Person sendromu, amfifizin, rijidite, paraneoplastik


Hüseyin Nezih Özdemir, Derya Yöndem, Seren Kaplan, Figen Gökçay. Stiff Person Syndrome-The Less Common Antibody: A Case Report. Turk J Neurol. 2020; 26(1): 39-41

Corresponding Author: Hüseyin Nezih Özdemir, Türkiye


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