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Volume : 23 Issue : 4 Year : 2017

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Fampridin therapy in multiple sclerosis; we should think twice! [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-65882

Fampridin therapy in multiple sclerosis; we should think twice!

Mohamed S A Mohamed
Department of Neurology, HWK1, Germany

Fampridin is a drug approved in US and EU as a supportive treatment for patients with certain neuromascular diseases, mainly multiple sclerosis. The drug improves the walking ability of the patient by enhancing the presynaptic nerve excitability. The drug acts through the inhibition of voltage gated potassium channels responsible for the establishment of early hyperpolarization. This paper tries to shed the light on a possible major risk of the drug, which is the worsening of the clinical outcome of any coincidentally occurring ischemic events.

Keywords: Multiple sclerosis, fampridin, ischemic- reperfusion injury




Corresponding Author: Mohamed S A Mohamed, Germany


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