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Heerfordt Syndrome: A Case Report [Turk J Neurol]
Turk J Neurol. 2010; 16(3): 144-148

Heerfordt Syndrome: A Case Report

Füsun Mayda Domaç1, Tuğrul Adıgüzel1, Temel Özden1, Gül Keskin2, Handan Mısırlı1
1Haydarpaşa Numune Training Ve Research Hospital, Department Of 1st Neurology,istanbul
2Haydapaşa Nemune Training And Research Hospital, Respiratory Medicine Outpatient Clinic,istanbul

Heerfordt syndrome is a form of neurosarcoidosis with the combination of fever, enlargement of the parotid gland, anterior uveitis, and facial nerve paralysis. We present a 38-year-old female patient who had a solid and painful swelling behind each ear 20 days after the complaints of redness of both eyes, fatigue, night sweat, and weight loss. Three weeks later, right facial paralysis developed, and the patient was seen in our outpatient clinic. On physical examination, bilateral solid and painful masses were observed on the parotid glands. Neurological examination was normal except for the right facial nerve paralysis. Ophthalmologic examination revealed bilateral anterior uveitis. Cranial magnetic resonance imaging was normal. On parotid gland magnetic resonance imaging, enlargement, lobulation and cystic lesions on both parotid glands with heterogeneous contrast involvement were observed. Parotid biopsy showed non-necrotizing granulomatous sialadenitis. There were multiple nodules on both lungs on mediastinum computerized tomography. Laboratory tests revealed: C-reactive protein 0.75 mg/dL, erythrocyte sedimentation rate 26 mm/hour and angiotensin-converting enzyme 83 U/L (N: 8-52 U/L) Though the patient, diagnosed as Heerfordt syndrome, had phase 1 sarcoidosis, she was treated with 45 mg/day steroid because of the multiple organ involvement. In conclusion, Heerfordt syndrome, a rare manifestation of neurosarcoidosis, must be kept in mind in the differential diagnosis of facial nerve paralysis.

Keywords: Uveoparotid fever, sarcoidosis, facial paralysis.


Füsun Mayda Domaç, Tuğrul Adıgüzel, Temel Özden, Gül Keskin, Handan Mısırlı. Heerfordt Syndrome: A Case Report. Turk J Neurol. 2010; 16(3): 144-148

Corresponding Author: Füsun Mayda Domaç, Türkiye


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