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The Effect of Different ApoE Genotypes and Other Risk Factors on Obstructive Sleep Apnea Syndrome Formation [Turk J Neurol]
Turk J Neurol. 2017; 23(4): 199-204 | DOI: 10.4274/tnd.54521  

The Effect of Different ApoE Genotypes and Other Risk Factors on Obstructive Sleep Apnea Syndrome Formation

Deniz Kıraç1, Özge Yağcıoğlu Yassa2, Hazal Gezmiş1, Saime Füsun Mayda Domaç2, Elif Çiğdem Altunok3, Ece Genç4
1Yeditepe University Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
2Health Sciences University Erenköy Mental and Nervous Diseases Training and Research Hospital, Department of Neurology, Istanbul, Turkey
3Yeditepe University Faculty of Medicine, Department of Biostatistics, Istanbul, Turkey
4Yeditepe University Faculty of Medicine, Department of Medical Pharmacology, Istanbul, Turkey

Objective: Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by partial or complete narrowing of the pharyngeal airway during sleep. In this study it was aimed to investigate the relation between OSAS and different variants of the ApoE gene, and to identify other risk factors that may affect the development of the disease.
Materials and Methods: Fifty-two patients with OSAS and 50 healthy volunteers were enrolled into the study. After collecting the necessary information associated with OSAS from the individuals, DNA was isolated from blood. ε2, ε3 and ε4 variants of Apolipoprotein E (ApoE) gene were investigated using real-time polymerase chain reaction.
Results: When the groups were compared with each other, age, body mass index, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, neck circumference, waist circumference, apnea hypopnea index, Epworth sleepiness scale, smoking, and daytime sleepiness were found statistically significant. The ε2 variant was found statistically high in the control group. Also, waist circumference, triglyceride and LDL levels were found statistically low in individuals with the ε2 genotype. In addition, triglyceride levels were found statistically high in individuals with the ε4 genotype.
Conclusion: The presence of the ε2 variant in healthy individuals may have a protective effect against OSAS. In addition, the relation between different variants of ApoE with LDL and triglyceride levels demonstrates the overlap of genotype and phenotype data.

Keywords: Obstructive sleep apnea syndrome, ApoE, real-time polymerase chain reaction


Deniz Kıraç, Özge Yağcıoğlu Yassa, Hazal Gezmiş, Saime Füsun Mayda Domaç, Elif Çiğdem Altunok, Ece Genç. The Effect of Different ApoE Genotypes and Other Risk Factors on Obstructive Sleep Apnea Syndrome Formation. Turk J Neurol. 2017; 23(4): 199-204

Corresponding Author: Deniz Kıraç, Türkiye


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