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Volume : 23 Issue : 3 Year : 2017

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Effects of Different ApoE Genotypes and Other Risk Factors to the Development of Obstructive Sleep Apnea Syndrome [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-54521

Effects of Different ApoE Genotypes and Other Risk Factors to the Development of Obstructive Sleep Apnea Syndrome

Deniz Kıraç1, Özge Yağcıoğlu Yassa2, Hazal Gezmiş1, Saime Füsun Mayda Domaç2, Elif Çiğdem Altunok3, Ece Genç4
1Faculty of Medicine, Department of Medical Biology, Yeditepe University, Istanbul, Turkey
2Department of Neurology, Health Sciences University, Erenköy Mental and Nervous Diseases Training and Reserach Hospital, Istanbul, Turkey
3Faculty of Medicine, Department of Biostatistics, Yeditepe University, Istanbul, Turkey
4Faculty of Medicine, Department of Medical Pharmacology, Yeditepe University, Istanbul, Turkey

Objective: Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by partial or complete narrowing of the pharyngeal airway during sleep. In this study it was aimed to investigate the relation between OSAS and different variants of ApoE gene and to investigate other risk factors which may effect the development of the disease.
Materials and Methods: Fifty two OSAS patients and 50 healthy volunteers were enrolled into the study. After collecting the necessary information associated with OSAS from the individuals, DNA was isolated from blood. ε2, ε3 and ε4 variants of ApoE gene were investigated by real-time polymerase chain reaction (RT-PCR).
Results: When groups were compared with each other, age, body mass index, total cholesterol, low density lipoprotein (LDL), high density lipoprotein, trigliseride, neck circumference, waist circumference, apnea hypopnea index, Epworth sleepiness scale, smoking and daytime sleepiness were found statistically significant. ε2 variant was found statistically high in control group. Also waist circumference, trigliseride and LDL levels were found statistically low in individuals who have ε2 genotype. In addition trigliseride levels were found statistically high in individuals who have ε4 genotype.
Conclusion: Presence of ε2 variant in healthy individuals may have a protective effect for OSAS. In addition, the relation between different variants of ApoE with LDL and trigliseride levels demonstrate the overlap of genotype and phenotype data.

Keywords: OSAS, ApoE, RT-PCR




Corresponding Author: Deniz Kıraç, Türkiye


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