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Effect of Deep Brain Stimulation on Quality of Life in Parkinson’s Disease Patients [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-49260

Effect of Deep Brain Stimulation on Quality of Life in Parkinson’s Disease Patients

Esra Dogru Huzmeli1, Atilla Yilmaz2
1Mustafa Kemal University School of Physical Therapy and Rehabilitation
2Mustafa Kemal University Tayfur Ata Sokmen Medicine Faculty Neurosurgery Department

Objective: The study aimed to investigate the effect of deep brain stimulation (DBS) on the quality of life (QOL) in patients with Parkinson’s Disease (PD).
Materials and Methods: The study included 19 patients with idiopathic PD who underwent DBS surgery at XXXXXXX University Medicine Faculty Neurosurgery Department. Patient characteristics, duration of disease, and the dominant hand of each patient were noted from the clinical records of the patients. The QOL of the patients was assessed using the RAND 36-Item Health Survey 1.0 (RAND-36) and the symptoms of PD were evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS), which was administered preoperatively when the medication was on (within one week prior to surgery) and postoperatively when the medication and stimulation were on (2 months after the surgery; range, 55-65 days).
Results: The study included 19 patients with PD, comprising 12 (63.2%) men and 7 (36.8%) females with a mean age of 52.07±9.89 (range, 38-72) years. Mean duration of disease was 6.60±5.92 years. A gender-based analysis on the RAND-36 scores indicated that there was a significant difference between the pre- and post-operative scores of the female patients for bodily pain (p=0.028) and between the pre- and post-operative scores of the male patients for emotional well-being (p=0.032). However, no significant difference was found between the pre- and post-operative scores of other subcategories in both genders (p>0.05). On the other hand, postoperative UPDRS scores decreased compared to preoperative scores in all the patients.
Conclusion: This study is the first region-wide prospective study to investigate the effects of STN-DBS in PD patients for our region. The results indicated that the STN–DBS surgery has a positive effect on the quality of life in PD patients.

Keywords: deep brain stimulation, quality of life, Parkinson’s disease




Corresponding Author: Esra Dogru Huzmeli, Türkiye


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