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Volume : 23 Issue : 3 Year : 2017

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Turkish Journal of Neurology Indexed By

Intravenous Thrombolytic Therapy in Acute Ischemic Stroke: The Experience of Kütahya [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-35651

Intravenous Thrombolytic Therapy in Acute Ischemic Stroke: The Experience of Kütahya

Mustafa Çetiner1, Sibel Canbaz Kabay1, Hasan Emre Aydın2
1University, Faculty of Medicine, Department of Neurology, Kutahya, Turkey
2University, Faculty of Medicine, Department of Neurosurgery, Kutahya, Turkey

Objective: Stroke is a serious cause of mortality and disability. Also the family of the patients may be adversely affected by this situation. On the other hand it has a big economic burden on the health. Significant progress has been achieved in the field of diagnosis, treatment and care in acute phase of the ischemic stroke, in recent years. Recombinant tissue plasminogen activator (r-tPA) and intravenous (iv) thrombolytic therapy are the main treatment options in selected patients. The aim of our study is to share the results of iv. thrombolytic therapy which applied in our clinic in acute ischemic stroke patients.
Materials and Methods: We evaluated the clinical data of the 52 patients whom were admitted with the diagnosis of ischemic stroke to our clinic within the first 4,5 hours after onset of stroke symptoms, and had treated with intravenous thrombolytic therapy, between the years May 2014 and June 2016. Demographic characteristics and clinical data were recorded.
Results: Of the patients 23 were male and 29 were female. The mean age was 70,7±12,8 (41-92). Intracranial hemorrhage after treatment was observed in 8 patients (15,4%). Of these, 6 patients (11,5%) had asymptomatic hemorrhage, 2 patients (3,8%) had symptomatic hemorrhage. The mean score of mRS was in sixteen patients (30,8%) 0-1, 10 patients (19,2%) 2-3 and 13 patients (25%) 4-5. The mean mRS score of seven patients with TACI ( 20%) was 0-1. The mean mRS score of eight patients with PACİ (57,1%) was 0-1. Thirteen patients (25%) died within 3 months after the treatment.
Conclusion: Intravenous thrombolytic therapy is an effective and safe treatment that is easy to administer within 4,5 hours in acute ischemic stroke patients. This treatment increases the number of ambulatory patients and reduces disability in selected patients.

Keywords: Acute ischemic stroke, thrombolytic therapy, disability.

Corresponding Author: Mustafa Çetiner, Türkiye

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