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Factors Associated with Prognosis in Patients with Guillain-Barré Syndrome [Turk J Neurol]
Turk J Neurol. 2019; 25(3): 140-145 | DOI: 10.4274/tnd.galenos.2019.34445  

Factors Associated with Prognosis in Patients with Guillain-Barré Syndrome

Mustafa Çetiner1, Murat Seyit2, Gönül Akdağ3, Hayri Demirbaş4, Özge Temel1, Sibel Canbaz Kabay1
1Kutahya University of Health Sciences Faculty of Medicine, Department of Neurology, Kutahya, Turkey
2Kutahya Evliya Celebi Training and Research Hospital, Clinic of Emergency Medicine, Kutahya, Turkey
3Kutahya Evliya Celebi Training and Research Hospital, Clinic of Neurology, Kutahya, Turkey
4Afyonkarahisar University of Health Sciences Faculty of Medicine, Department of Neurology, Afyonkarahisar, Turkey

Objective: We aimed to evaluate the demographic, clinical, laboratory and electrophysiological findings of patients with inpatient Guillain-Barré syndrome in our clinics and to investigate the effect of these parameters on the prognosis of the disease.
Materials and Methods: Between January 2014 and April 2018, file records of patients admitted to our clinics with the diagnosis of Guillain-Barré syndrome were retrospectively reviewed. Demographic characteristics, clinical, laboratory and electrophysiological findings of the patients at the time of admission were recorded. Patients were clinically graded according to the Hughes classification at the time of admission and on the 3rd month after discharge.
Results: In the study, 25 of the 51 patients were male (49%) and 26 were female (51%) and the mean age was 54.21±17.32 years. According to clinical and electrophysiologic diagnosis, 34 patients (66.7%) had acute inflammatory demyelinating polyradiculoneuropathy, 9 patients (17.6%) had acute motor axonal neuropathy, 6 patients (11.8%) had acute motor sensory axonal neuropathy and 2 patients (3.9%) had Miller Fisher syndrome. According to Hughes scoring on the 3rd month after discharge, 31 patients (60.8%) had in good prognosis (Hughes score ≤2) and 20 patients (39.2%) had in poor prognosis group (Hughes score >2). In the comparison between the two groups according to clinical, demographic, and laboratory parameters, older age (≥50), high Hughes score at admission, weakness in extremities as first complaint, the presence of complications, need for mechanical ventilation and presence of gastroenteritis as a leading infection were evaluated as prognostic factors.
Conclusion: The most common variant of Guillain-Barré syndrome in our study was acute inflammatory demyelinating polyradiculoneuropathy. Older age (≥50), high Hughes score at admission, weakness in extremities as the first symptom, presence of complications, need for mechanical ventilation, and presence of gastroenteritis as a precursor infection were poor prognostic factors.

Keywords: Guillain-Barré syndrome, clinical findings, prognosis


Mustafa Çetiner, Murat Seyit, Gönül Akdağ, Hayri Demirbaş, Özge Temel, Sibel Canbaz Kabay. Factors Associated with Prognosis in Patients with Guillain-Barré Syndrome. Turk J Neurol. 2019; 25(3): 140-145

Corresponding Author: Mustafa Çetiner, Türkiye


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