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Analysis of peripapillary retinal nerve fiber layer and macular volume in patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders and Healthy Controls with Spectral Domain Optical Coherence Tomography in a Turkish cohort. [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-33230

Analysis of peripapillary retinal nerve fiber layer and macular volume in patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders and Healthy Controls with Spectral Domain Optical Coherence Tomography in a Turkish cohort.

Ayşe İlksen Çolpak1, Duygu Gülmez Sevim2, Aslı Kurne1, Sevda Diker1, Rana Karabudak1, Sibel Kadayıfçılar2, Tülay Kansu1
1Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
2Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Objective: To compare the peripapillary retinal nerve fiber layer (pRNFL) thickness and macular volume in patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and healthy controls.
Materials and Methods: This study used spectral domain optical coherence tomography (SD-OCT) to measure pRNFL and the volume of retinal layers at the macula. Forty patients with MS or NMOSD and 19 healthy controls were enrolled.
Results: After at least one clinical episode of optic neuritis, the average pRNFL for NMOSD [60µm (34-105)] and MS patients [85µm (41-109)] were lower than healthy controls [99µm (88-109)] and NMOSD patients had significantly lower pRNFL compared to MS patients (p=0.002). Foveal volume did not differ between ON eyes of NMOSD and MS patients (NMOSD 1.18±0.3mm³, MS 1.82±2.07mm). Mean pRNFL values in seronegative NMOSD eyes [58µm (47-111)] tended to be thinner compared to seropositive NMOSD eyes [76µm (42-105)]. This finding wasn’t considered to be statistically significant.
Conclusion: Our study revealed that both foveal (area in 1.5 mm ETDRS ring) and total macular volume (area in 6 mm ETDRS ring) were lower in both MS and NMOSD patients compared to healthy controls. Optic neuritis of NMOSD is associated with a thinner average retinal nerve fiber layer compared to MS, suggesting earlier axonal injury in the affected optic nerves.

Keywords: neuromyelitis optica, optical coherence tomography, multiple sclerosis, optic neuritis




Corresponding Author: Ayşe İlksen Çolpak, Türkiye


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