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Analysis of Peripapillary Retinal Nerve Fiber Layer and Macular Volume in Patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, and Healthy Controls Using Spectral Domain Optical Coherence Tomography in a Turkish Cohort [Turk J Neurol]
Turk J Neurol. 2019; 25(1): 26-31 | DOI: 10.4274/tnd.galenos.2018.33230  

Analysis of Peripapillary Retinal Nerve Fiber Layer and Macular Volume in Patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, and Healthy Controls Using Spectral Domain Optical Coherence Tomography in a Turkish Cohort

Ayşe İlksen Çolpak1, Duygu Gülmez Sevim2, Aslı Tuncer1, Sevda Diker1, Rana Karabudak1, Sibel Kadayıfçılar2, Tülay Kansu1
1Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey
2Hacettepe University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

Objective: To compare the peripapillary retinal nerve fiber layer (pRNFL) thickness and macular volume in patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and healthy controls.
Materials and Methods: This study used spectral domain-optical coherence tomography to measure pRNFL and the volume of retinal layers at the macula. Forty patients with MS or NMOSD and 19 healthy controls were enrolled.
Results: After at least one clinical episode of optic neuritis, the average pRNFL for NMOSD [60 µm (34-105)] and patients with MS [85 µm (41-109)] were lower than in healthy controls [99 µm (88-109)], and patients with NMOSD had significantly lower pRNFL compared with patients with MS (p=0.002). Foveal volume did not differ between optic neuritis eyes of patients with NMOSD and MS (NMOSD 1.18±0.3 mm3, MS 1.82±2.07 mm3). The mean pRNFL values in seronegative NMOSD eyes [58 µm (range, 47-111)] tended to be thinner compared with seropositive NMOSD eyes [76 µm (range, 42-105)]. This finding was not considered to be statistically significant.
Conclusion: Our study revealed that both foveal (area in a 1.5 mm ETDRS ring) and total macular volume (area in a 6 mm ETDRS ring) were lower in both patients with MS and NMOSD compared with healthy controls. Optic neuritis of NMOSD is associated with a thinner average RNFL compared with MS, suggesting earlier axonal injury in the affected optic nerves.

Keywords: Neuromyelitis optica, optical coherence tomography, multiple sclerosis, optic neuritis


Ayşe İlksen Çolpak, Duygu Gülmez Sevim, Aslı Tuncer, Sevda Diker, Rana Karabudak, Sibel Kadayıfçılar, Tülay Kansu. Analysis of Peripapillary Retinal Nerve Fiber Layer and Macular Volume in Patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, and Healthy Controls Using Spectral Domain Optical Coherence Tomography in a Turkish Cohort. Turk J Neurol. 2019; 25(1): 26-31

Corresponding Author: Ayşe İlksen Çolpak, Türkiye


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