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The relation between serum P-Selectin, Thrombin Activatable Fibrinolysis Inhibitor (TAFI) levels and carotid artery intima-media thickness in acute ischemic stroke [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-26096

The relation between serum P-Selectin, Thrombin Activatable Fibrinolysis Inhibitor (TAFI) levels and carotid artery intima-media thickness in acute ischemic stroke

Dilek Yılmaz1, Seda Aladag Kurt2, Aslıhan Onay2, Resul Karakus2, Belgin Koçer2
1Konya Numune State Hospital
2Gazi University, Medical Faculty

Objective: IInflammation and migration of leukocytes to brain parenchyma play a role in atherosclerosis and cerebral ischemic stroke. Migration occurs with the help of adhesion molecules on the surface of cerebral endothelial cells and leukocytes. P-selectin, an adhesion molecule, is present on the platelet and endothelial surface and allows leukocytes to loosely adhere to the endothelium, and its increase has been shown in acute ischemic stroke (AIS). Thrombin activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase molecule that can be another marker of AIS, which been shown to increase the risk of thromboembolism and stroke 6-fold. Intima-media thickness (IMT) is thought to be associated with atherosclerotic diseases in carotid ultrasound and increased risk of ischemic stroke has been found to be associated with increased carotid IMT. In this study, we investigated the relationship between p-selectin and TAFI levels, which have been shown to be effective for AIS via carotid IMT, that is considered significant for atherosclerosis.

Materials and Methods: Forty patients with AIS and 22 healthy subjects were included in the study. In both groups, serum p-selectin and TAFI levels were studied at the time of application, 7th day, 14th day and 1st month; carotid IMT and stenosis rates were measured by Doppler USG. P-selectin and TAFI levels were compared with carotid IMT in both groups.
Results: There was no significant difference between p-selectin levels and carotid IMT between the groups; TAFI levels were significantly higher in the patient group and were correlated with carotid IMT in both groups.

Conclusion: TThe positive correlation between increased P-selectin levels in AIS and carotid IMT were not detected in our study; however, a positive correlation between TAFI levels and carotid IMT and stenosis rates have been reported. TAFI increase has been suggested to be a marker of early atherosclerosis in asymptomatic atherosclerosis and ischemic stroke.

Keywords: Ischemic stroke, P-selectin, thrombin-activatable fibrinolysis inhibitor (TAFI), carotid intima-media thickness (IMT)




Corresponding Author: Dilek Yılmaz, Türkiye


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