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Volume : 25 Issue : 4 Year : 2019

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Clobazam usage in the treatment of resistant epilepsy patients: retrospective clinical data [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-22755

Clobazam usage in the treatment of resistant epilepsy patients: retrospective clinical data

Damla Cetinkaya, Seher Naz Yeni
Department Of Neurology, Istanbul-Cerrahpasa University Cerrahpasa Faculty Of Medicine, Istanbul, Turkey

Objective: Patients with drug resistant focal or generalized epilepsy are important in terms of treatment and polytherapy necessity, side effect profile of drugs and seizure control difficulties. Clobazam(CLB) which has less sedative effect than other benzodiazepines is frequently used in different countries. In this study, we aimed to present the results related to the demographic characteristics, side effects and treatment efficacy of the patients under CLB treatment.
Materials and Methods: The patients who were followed-up in the outpatient clinic of the Cerrahpaşa Medical Faculty were screened retrospectively. Gender, age of seizure onset, duration of epilepsy, seizure type, duration of drug use, frequency of seizures before and after CLB, drug side effects were investigated. The decrease in seizure frequency could not be quantitatively evaluated in some patients because the study was retrospective. For this reason, two groups have been identified as a significant reduction in seizure frequency and seizure-free according to the information provided by the parents and the recorded data.
Results: 41 patients with CLB who were followed in the epilepsy clinic were examined. The mean age of 26 male and 15 female patients was 30.30. The mean duration of epilepsy was 20.4 years. It was determined that 16 patients were observed with either seizure-free or intervening rare-mild seizures. There was a significant decrease in seizure frequency in 9 patients. There was observed headache in 1 patient, sedation and dizziness in 2 patients.

Conclusion: CLB is especially recommended for add-on therapy in Lennox-Gastaut Syndrome. In this study, it is observed that in focal / generalized, idiopathic / cryptogenic different groups, 39% of the patients were seizure-free. However, this effect was not lost during the mean follow-up period of 12.2 months. Although the value of this data decreases due to its retrospective nature, the place of CLB in the treatment of focal / generalized epilepsy is important.

Keywords: clobazam, refractory epilepsy, add-on therapy




Corresponding Author: Damla Cetinkaya, Türkiye


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