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The effect of abobotulinum toxin A in the prophylactic treatment of refractory migraine [Turk J Neurol]
Turk J Neurol. 2016; 22(4): 156-160 | DOI: 10.4274/tnd.15986  

The effect of abobotulinum toxin A in the prophylactic treatment of refractory migraine

Morteza Mazloum Farsi Baf1, Afrouz Alipour1, Mehran Homam2, Mostafa Khorashadizadeh1, Maedeh Beheshti Saadat1
1Islamic Azad University, Medical Branch, Mashhad, Iran
2Islamic Azad University, Department of Neurology, Mashhad Branch, Mashhad, Iran

Objective: Some patients with migraine headache still experience severe migraine attacks despite use of proper prophylactic treatments. There are several treatments for refractory migraine (RM), one of which is abobotulinum toxin A (Dysport). This study aimed to investigate the efficacy of abobotulinum toxin A in the prophylactic treatment of RM.
Materials and Methods: In this prospective single-arm clinical trial, 18 patients with RM were included. Patients completed a questionnaire including migraine characteristics one month before the study. Each patient received an injection of 150 U abobotulinum toxin A in the specific head and neck regions. Before and 3 months after treatment, migraine severity was evaluated.
Results: The average number of attacks per month before injection was 7.56±4.06, which decreased to 1.89±1.32 3 months after injection (p<0.0001). The
average duration of attacks also decreased significantly after 3 months of injection (from 20.33 hrs to 2.56 hrs per month) (p=0.0001). Three patients (16.6%) had
no attacks during the follow-up period. Eleven patients (61.1%) reported mild attacks and four patients (22.2%) reported moderate pain.
Conclusion: Abobotulinum toxin A (Dysport) can reduce frequency, duration, and severity of migraine attacks in patients with RM and it can be used as a prophylactic treatment in this group of patients.

Keywords: Refractory migraine, Abobotulinumtoxin A, headache


Dirençli Migrenin Profilaktik Tedavisinde Abobotulinum Toksin A Etkisi

Morteza Mazloum Farsi Baf1, Afrouz Alipour1, Mehran Homam2, Mostafa Khorashadizadeh1, Maedeh Beheshti Saadat1
1Islamic Azad University, Medical Branch, Mashhad, Iran
2Islamic Azad University, Department of Neurology, Mashhad Branch, Mashhad, Iran

Amaç: Migren hastalarının bir kısmı uygun profilaktik tedavi kullanımına rağmen ciddi migren atakları yaşamaya devam etmektedirler. Dirençli migrende kullanılan çeşitli tedaviler vardır ve bunlardan birisi abobotulinum toksin A’dır (Dysport). Bu çalışmada dirençli migrenin profilaktik tedavisinde abobotulinum toksin A’nın etkinliğinin araştırılması hedeflenmiştir.
Gereç ve Yöntem: Bu prospektif tek kollu klinik çalışmaya 18 dirençli migren hastası dahil edildi. Hastalar çalışmadan 1 ay önce migren karakteristiklerini içeren bir anketi tamamladılar. Her hastanın spesifik baş ve boyun bölgelerine 150 U abobotulinum toksin A enjeksiyonu uygulandı. Tedavi öncesi ve 3 ay sonrasında migren şiddeti değerlendirildi.
Bulgular: Enjeksiyon öncesi aylık ortalama atak sayısı 7,56±4,06 iken, enjeksiyondan 3 ay sonra bu sayı 1,89±1,32’ye geriledi (p<0,0001). Ortalama atak süresinin de enjeksiyondan 3 ay sonra anlamlı olarak azaldığı görüldü (ayda 20,33 saatten 2,56 saate) (p=0,0001). İzlem süresince üç hastada (%16,6) hiç atak gözlenmezken, 11 hasta (%61,1) hafif, dört hasta ise (%22,2) orta şiddette ataklar bildirdi.
Sonuç: Abobotulinum toksin A (Dysport) dirençli migren hastalarının atak sıklığı, süresi ve ciddiyetini azaltabilir ve bu hasta grubunda profilaktik tedavi olarak kullanılabilir.

Anahtar Kelimeler: Dirençli migren, abobotulinum toksin A, baş ağrısı


Morteza Mazloum Farsi Baf, Afrouz Alipour, Mehran Homam, Mostafa Khorashadizadeh, Maedeh Beheshti Saadat. The effect of abobotulinum toxin A in the prophylactic treatment of refractory migraine. Turk J Neurol. 2016; 22(4): 156-160

Corresponding Author: Morteza Mazloum Farsi Baf, Iran


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