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Volume : 25 Issue : 1 Year : 2019

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Evaluation of CRP/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-13334

Evaluation of CRP/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

Tamer Yazar1, Hülya Olgun Yazar2
1Ordu State Hospital
2Ordu University Research and Training Hospital

Objective: Identification of serum c-reactive protein (CRP)/albumin ratio according to disease stage in idiopathic Parkinson disease (IPD) with the aim of collecting data about the role of inflammation and oxidative stress in etiopathogenesis and possible effects on disease progression.
Materials and Methods: The study was completed with 151 patients with staging according to Modified Hoehn and Yahr (H&Y) criteria and 150 healthy volunteers in the same age interval as patients. Our retrospective study applied the Unified Parkinson disease rating scale (UPDRS) and H&Y scales to patients with IPD diagnosis according to “United Kingdom Parkinson Disease Society Brain Bank” diagnostic criteria. Patient and control groups had venous blood samples taken for biochemical study after 12-14 hours fast.
Results: The serum albumin levels were low, while serum CRP levels and CRP/albumin ratios were observed to be high in the IPD group (p<0.05). Serum levels of CRP/albumin ratio were identified to statistically significantly increase in parallel with the progression of disease stage (p<0.05).
Conclusion: Our study supports the hypothesis that CRP/albumin ratio as a biomarker of the inflammation and oxidative stress may be used as a marker of IPD etiopathogenetic process. For identification of chronic progressive diseases like IPD in the initial stages and to be able to take precautions, assessment of variations in easily accessible and low-cost parameters like serum CRP/albumin ratio is important.

Keywords: İdiopathic Parkinson Disease, İnflammation, CRP/albumin ratio, Oxidative Stress, Disease Stage




Corresponding Author: Tamer Yazar, Türkiye


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