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Volume : 23 Issue : 3 Year : 2017

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Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine [Turk J Neurol]
Turk J Neurol. 2017; 23(3): 117-121 | DOI: 10.4274/tnd.09216  

Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine

Yasemin Eren1, Ebru Bilge Dirik2, Salim Neşelioğlu3, Özcan Erel3
1Health Sciences University, Diskapi Yildirim Beyazit Training and Research Hospital, Clinic of Neurology, Ankara, Turkey
2Ataturk Training and Research Hospital, Clinic of Neurology, Ankara, Turkey
3Yildirim Beyazit University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey

Objective: Paraoxonase 1 (PON1) is associated with high-density lipoprotein (HDL) and inhibits low-density lipoprotein (LDL) oxidation. The antioxidant and antiatherogenic characteristics of HDL are attributed to this feature. The mechanisms defined in the vascular atherosclerotic process, such as inflammation, oxidative stress, and endothelial dysfunction, are also present in migraine pathophysiology. The association between hyperlipidemia and migraine has been described in various studies; however, different results have been reported. We aimed to evaluate the general lipid profiles and the relationship between PON1, arylesterase (ARE) activity, and HDL levels in patients with migraine.
Materials and Methods: The study group comprised 150 patients with migraine. The control group included 71 age- and sex-matched healthy subjects. None of the subjects in either group had any vascular risk factors. PON1 and ARE activities were evaluated using a method developed by Erel. Serum lipid levels were measured using an autoanalyzer (Roche Hitachi Cobas c501).
Results: Serum lipid profiles, PON1/ARE activity and HDL levels were similar to those of the control group. No statistical correlation was found between lipid parameters and PON1 or ARE levels in the patient and control groups.
Conclusion: According to our results, investigating PON1 and ARE activities may be meaningless whenever migraineurs have no vascular risk factors. On the other hand, studies of longer duration will be required to evaluate the longitudinal relationship between PON1 and ARE activity in the etiopathogenesis of migraine.

Keywords: Paraoxonase, arylesterase, high-density lipoprotein, migraine


Yasemin Eren, Ebru Bilge Dirik, Salim Neşelioğlu, Özcan Erel. Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine. Turk J Neurol. 2017; 23(3): 117-121

Corresponding Author: Yasemin Eren, Türkiye


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