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The assessment of behavior, learning, memory, apoptosis, neuronal damage and amount of GABA A alpha 1 receptor in immature and mature rats after status epilepticus [Turk J Neurol]
Turk J Neurol. Ahead of Print: TJN-08058

The assessment of behavior, learning, memory, apoptosis, neuronal damage and amount of GABA A alpha 1 receptor in immature and mature rats after status epilepticus

Ali Sönmez1, Mehmet Fatih Göl2, Füsun Ferda Erdoğan2, Narin Liman3, Ayşe Sönmez4
1Private Elbistan Life Hospital, Clinic of Neurology, Elbistan, Turkey
2Erciyes University School of Medicine, Department Of Neurology, Kayseri, Turkey
3Erciyes University Faculty of Veterinary, Department of Histology and Embryology, Kayseri, Turkey
4Elbistan State Hospital, Clinical Nurse, Elbistan, Turkey

Objective: In this study we aimed evaluate to age dependent cognitive and behavioral changes,neuronal damage and the amount of GABA A alpha 1 in immature, mature and adolescant rats after status epilepticus.
Materials and Methods: In immature(17 days),adolescant(45 days) and mature(150 days) rats occured pentylenetetrazole induced status epilepticus(SE).After SE adolescant and mature rats underwent open field test and Morris water maze test.After behavioral tests we performed to immature,adolescant and mature rats histological investigation to assess neuronal cell damage(caspase and calpain activity) and amount of GABA A alpha 1 receptor and compared with control groups.
Results: There are no statistically significant differences between control and experimental groups in behavioral tests in early stage after SE.In mature rats observed calpain mediated neuronal damage with necrotic morphology after SE,but in adolescant and pups rats not observed.In immature rat(17 days) observed caspase mediated neuronal damage with apoptotic morphology after SE.In the three experimental groups the amount of GABA A Alpha 1 receptor has decreased compared with control groups.The decrease of amount of GABA A alpha 1 receptor is most highly in mature experimental group.The amount of GABA A alpha 1 receptor in hippocampus decreased to level of higher than in cortex.
Conclusion: This study show that there is no negative impact on learning and behavioral functions in early stage after PTZ-induced SE,but histologically lead to necrosis dominant calpain and caspase mediated neuronal damage,calpain-mediated cell necrosis is seen particularly in the mature group and caspase-dependent apoptotic morphology observed in immature rats.The decreased of GABA A alpha 1 receptor is most higher in the adults.Our study support that status epilepticus induced cell damage is more pronounced with increasing age,and calpain-mediated cell damage that can clearly be observed in the mature group.To understand the long term effect of SE-dependent neuronal damage on cognition and behavior we need to long-term follow-up study.

Keywords: Memory, calpain, caspase, GABA receptor, status epilepticus, mature and immature rat




Corresponding Author: Mehmet Fatih Göl, Türkiye


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